I am building a Zenith Extreme on a P5. The E-ATX completely covers the main wire pass through ports. What I did is get some very tall standoffs. Of course this means you must use the vertical riser setup for the GPU. Also, I am just finding out that the IO shield interferes with the tempered glass mounting block. I am thinking about machining the corner of the block to make clearance. If you are just using the front panel, or the plexi kit that only has the front, shouldn't be a problem. Building this system has taken many hours already! I still have time since my waterblock is still on backorder.