I have the exact same issue, software wont open if i have the controllers plugged in. As soon as i unplug the controller, software will open.
It worked for about a week when i discovered how to turn off the inactive fan slots. But recently started booting again in its default RGB setting.
If i delete the TT folder in appdata, the software will open, but i have to delete it every time I turn on my computer to get it to work again.
I have 6 fans with 2 controllers. I opened a ticket with thermaltake about 3 weeks ago but never received a response.
