Sorry to zombie this thread but I am having the same issue and nothing is working. I have uninstalled TT RGB Plus 1.44, I have deleted the TT folder down in AppData, rebooted, reinstalled 2.0.9. It installs and shows minimized but when I select launch RGB Plus, a blank icon shows temporarily on the task bar and then disappears.
After install, I did get the dialog for the warning for epileptics, but that's about the only UI I have seen from this software. I have also deleted an old 2020 ene.sys.
I DO have core isolation turned on, so I will try it with that off.
EDIT: Turning off core isolation did not fix things. Upon boot, the thermatake logo shows, it warns about epilepsy, but Launch does nothing.