I have been having a very similar issue since August 2017. After sleeping the Thermaltake software becomes frozen. I have to close and re-open the program to get functionality back. The system boots faster than the USB can initialize. I have disabled ever power saving feature with no success. This is on a Gigabyte gaming 9 z270 board. My MVME is so fast I just shutdown and forgo sleeping. My boot up is as fast as sleep. If this problem ever gets solved I would be amazed.